The genetic association of vitamin D receptor polymorphisms and cervical spondylotic myelopathy in Chinese subjects.

Abstract

BACKGROUND:

The association of vitamin D receptor (VDR) gene polymorphisms to the lumbar degenerative disc disease has been previously studied; however, the role of VDR gene polymorphisms in cervical spondylosis remains unknown.

METHODS:

One hundred fifty four patients with cervical spondylotic myelopathy (CSM) and 156 controls were enrolled. The clinical characteristics were collected and the severity of cervical spondylotic myelopathy was evaluated by magnetic resonance imaging (MRI). The VDR polymorphism genotyping was performed.

RESULTS:

No significant difference in clinical characteristics was noted between the case and controls. For ApaI polymorphism, the cases had a marked higher prevalence of AA genotype (19.5% vs. 8.3%, P=0.003) and A allele frequencies (34.4% vs. 22.4%, P<0.001) than controls. For TaqI polymorphism, the cases had a significant higher prevalence of TT genotype (67.5 vs. 44.2%, P<0.001) and T allele frequencies (76.9% vs. 54.2%, P<0.001) than controls. The odds ratio for CSM was 2.88 for the ApaI A allele carriers and 4.67 for the TaqI T allele carriers. The TaqI genotypes, both TT and TC showed a markedly higher MRI severity grading level than CC genotype (both P<0.01, compared with CC genotype).

CONCLUSION:

Certain VDR polymorphism is related in the presence and severity of CSM in Chinese subjects.

• Authors: Zhan Chao Wang, Xiong Sheng Chen, Da Wei Wang, Jian Gang Shi, Lian Shun Jia, Guang Hui Xu, Jian Hou Huang, Lei Fan
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 411 Issue 11-12 Pg. 794-7 (Jun 03 2010) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 20144597 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010. Published by Elsevier B.V.

Chemical References

• Receptors, Calcitriol
• Deoxyribonucleases, Type II Site-Specific
• GGGCCC-specific type II deoxyribonucleases
• TCGA-specific type II deoxyribonucleases

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• Deoxyribonucleases, Type II Site-Specific (genetics)
• Female
• Genetic Association Studies (methods)
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Receptors, Calcitriol (genetics)
• Severity of Illness Index
• Spinal Cord Diseases (diagnosis, genetics)
• Spondylosis (diagnosis, epidemiology, genetics)