Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with X-linked retinoschisis.

Abstract

OBJECTIVE:

To determine the efficacy of sustained topical therapy with dorzolamide hydrochloride, 2%, on visual acuity and cystic macular lesions in patients with juvenile X-linked retinoschisis (XLRS).

DESIGN:

Retrospective analysis.

SETTING:

University hospital, tertiary care referral center.

PATIENTS:

Twenty-nine eyes of 15 patients with XLRS receiving treatment with the topical dorzolamide formulation for 4 to 41 months were enrolled.

MAIN OUTCOME MEASURES:

Changes in visual acuity, cystic macular lesions, and central foveal zone thickness on optical coherence tomography during follow-up for the duration of treatment.

RESULTS:

Among the 15 patients with XLRS, 20 eyes (69%) of 11 patients showed a positive response to treatment. Five of the 20 eyes (25%) in 3 of the 11 patients showed an initial response and a subsequent rebound of macular cysts. In 4 eyes (14%) of 3 patients, there was no response to treatment, but the macular cysts did not worsen compared with the baseline level. In 5 additional eyes (17%) of 4 patients, there was no response to treatment, and the macular cysts worsened when compared with the baseline level. Sixteen eyes (55%) of 12 patients had improvement in best-corrected visual acuity by at least 7 letters in at least 1 eye at the most recent follow-up visit. Seventeen eyes (59%) of 10 patients showed a reduction in the central foveal zone thickness in at least 1 eye when compared with the pretreatment level.

CONCLUSION:

Patients with XLRS have the potential to experience a beneficial effect from sustained treatment with dorzolamide, 2%.

• Authors: Mohamed A Genead, Gerald A Fishman, Saloni Walia
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 128 Issue 2 Pg. 190-7 (Feb 2010) ISSN: 1538-3601 [Electronic] United States
• PMID: 20142541 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Carbonic Anhydrase Inhibitors
• Eye Proteins
• Ophthalmic Solutions
• RS1 protein, human
• Sulfonamides
• Thiophenes
• dorzolamide

Topics

• Administration, Topical
• Adolescent
• Adult
• Carbonic Anhydrase Inhibitors (administration & dosage)
• Eye Proteins (genetics)
• Follow-Up Studies
• Humans
• Intraocular Pressure (drug effects)
• Macular Edema (diagnosis, drug therapy, physiopathology)
• Middle Aged
• Ophthalmic Solutions (administration & dosage)
• Retinoschisis (drug therapy, genetics, physiopathology)
• Retrospective Studies
• Sulfonamides (administration & dosage)
• Thiophenes (administration & dosage)
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Acuity (physiology)
• Young Adult