Lack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patients.

Abstract

AIM:

To investigate the SLCO1B1 388A>G and 521T>C polymorphisms in hyperlipidemia patients and evaluate the effect of the two polymorphisms on the lipid-lowering efficacy of pitavastatin.

METHODS:

The functional polymorphisms of SLCO1B1 (388A>G and 521T>C) were genotyped in 140 Chinese patients with essential hyperlipidemia using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and one-step tetra-primers ARMS-PCR. Eighty-five patients were enrolled in the clinical trial and given 2 mg of pitavastatin daily for 8 weeks. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) serum levels were measured at baseline, after 4 weeks and after 8 weeks of treatment.

RESULTS:

The allele frequencies of SLCO1B1 388A>G and 521T>C in essential hyperlipidemia patients were 71.1% and 11.1%, respectively. The 4- and 8-week treatment with pitavastatin significantly reduced TC, TG, and LDL levels, but there was no statistical difference among patients with wild type, SLCO1B1 388A>G or SLCO1B1 521T>C in the lipid-lowering efficacy of pitavastatin.

CONCLUSION:

The present study found that the allele frequencies of SLCO1B1 388A>G and 521T>C in Chinese patients with essential hyperlipidemia are comparable to those in healthy Chinese population. SLCO1B1 388A>G and 521T>C do not affect the lipid-lowering efficacy of pitavastatin.

• Authors: Guo-ping Yang, Hong Yuan, Bin Tang, Wei Zhang, Lian-sheng Wang, Zhi-jun Huang, Dong-sheng Ou-Yang, Gui-xiang Zhang, Hong-hao Zhou
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 31 Issue 3 Pg. 382-6 (Mar 2010) ISSN: 1745-7254 [Electronic] United States
• PMID: 20140004 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Enzyme Inhibitors
• Hypolipidemic Agents
• Lipoproteins, HDL
• Lipoproteins, LDL
• Liver-Specific Organic Anion Transporter 1
• Organic Anion Transporters
• Quinolines
• SLCO1B1 protein, human
• Triglycerides
• Cholesterol
• pitavastatin

Topics

• Adolescent
• Adult
• Aged
• Asian People (genetics)
• Cholesterol (blood)
• Enzyme Inhibitors (pharmacology, therapeutic use)
• Female
• Gene Frequency
• Humans
• Hyperlipidemias (drug therapy, genetics)
• Hypolipidemic Agents (pharmacology, therapeutic use)
• Lipid Metabolism (drug effects)
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Liver-Specific Organic Anion Transporter 1
• Male
• Middle Aged
• Organic Anion Transporters (genetics)
• Polymorphism, Genetic
• Quinolines (pharmacology, therapeutic use)
• Triglycerides (blood)
• Young Adult