Abstract | BACKGROUND: Persistent symptoms after treatment for neuroborreliosis are common for reasons mainly unknown. These symptoms are often unspecific and could be caused by dysfunctions in endocrine systems, an issue that has not been previously addressed systematically. We therefore mapped hormone levels in patients with previous confirmed Lyme neuroborreliosis of different outcomes and compared them with a healthy control group. METHODS: Twenty patients of a retrospective cohort of patients treated for definite Lyme neuroborreliosis were recruited 2.3 to 3.7 years (median 2.7) after diagnosis, together with 23 healthy controls. Lyme neuroborreliosis patients were stratified into two groups according to a symptom/sign score. All participants underwent anthropometric and physiological investigation as well as an extensive biochemical endocrine investigation including a short high-dose adrenocorticotropic hormone stimulation (Synacthen) test. In addition to hormonal status, we also examined electrolytes, 25-hydroxy-vitamin D and interleukin-6. RESULTS: Eight patients (40%) had pronounced symptoms 2-3 years after treatment. This group had a higher cortisol response to synacthen as compared with both controls and the Lyme neuroborreliosis patients without remaining symptoms (p < 0.001 for both comparisons). No other significant differences in the various baseline biochemical parameters, anthropometric or physiological data could be detected across groups. CONCLUSIONS:
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Authors | Ivar Tjernberg, Martin Carlsson, Jan Ernerudh, Ingvar Eliasson, Pia Forsberg |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 10
Pg. 20
(Feb 05 2010)
ISSN: 1471-2334 [Electronic] England |
PMID | 20137075
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Interleukin-6
- Cosyntropin
- adrenocorticotropin zinc
- Hydrocortisone
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anthropometry
- Antibodies, Bacterial
(blood)
- Case-Control Studies
- Cosyntropin
(pharmacology)
- Female
- Humans
- Hydrocortisone
(blood)
- Interleukin-6
(blood)
- Lyme Neuroborreliosis
(diagnosis, metabolism)
- Male
- Middle Aged
- Retrospective Studies
- Treatment Outcome
- Young Adult
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