Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.

Abstract

AIMS:

To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC).

METHODS:

A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis.

RESULTS:

Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type.

CONCLUSIONS:

Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC.

• Authors: Jinna Shi, Shan Wang, Eryang Zhao, Lei Shi, Xin Xu, Ming Fang
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 39 Issue 7 Pg. 548-51 (Aug 01 2010) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 20136697 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Coloring Agents
• PXN protein, human
• Paxillin

Topics

• Adult
• Aged
• Carcinoma, Adenoid Cystic (pathology, secondary)
• Coloring Agents
• Cytoplasm (ultrastructure)
• Extracellular Space
• Female
• Histocytochemistry
• Humans
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Parotid Neoplasms (pathology)
• Paxillin (analysis)
• Salivary Gland Neoplasms (pathology)
• Salivary Glands, Minor (pathology)
• Submandibular Gland Neoplasms (pathology)
• Young Adult