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Antrocamphin A, an anti-inflammatory principal from the fruiting body of Taiwanofungus camphoratus , and its mechanisms.

Abstract
The fungus Taiwanofungus camphoratus is commonly used for medicinal purposes in Taiwan. It is used as a detoxicant for food poisoning and considered to be a precious folk medicine for hepatoprotection and anti-inflammation. In this study, a lipopolysaccaride (LPS)-challenged ICR mouse acute inflammation model and a LPS-induced macrophage model were used to evaluate the anti-inflammatory activity of T. camphoratus. Ethanol extract of T. camphoratus significantly inhibited expression of iNOS and COX-2 in the liver of LPS-challenged acute inflammatory mice. The ethyl acetate fraction and its isolated compound, antrocamphin A, significantly suppressed nitrite/nitrate concentration in LPS-challenged RAW 264.7 cells. Antrocamphin A showed potent anti-inflammatory activity by suppressing pro-inflammatory molecule release via the down-regulation of iNOS and COX-2 expression through the NF-kappaB pathway. This study, therefore, first demonstrates the bioactive compound of T. camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.
AuthorsYu-Hsin Hsieh, Fang-Hua Chu, Ya-Shin Wang, Shih-Chang Chien, Shang-Tzen Chang, Jei-Fu Shaw, Chieh-Yin Chen, Wen-Wei Hsiao, Yueh-Hsiung Kuo, Sheng-Yang Wang
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 58 Issue 5 Pg. 3153-8 (Mar 10 2010) ISSN: 1520-5118 [Electronic] United States
PMID20128588 (Publication Type: Journal Article)
Chemical References
  • Alkynes
  • Anisoles
  • Anti-Inflammatory Agents
  • DNA Primers
  • antrocamphin A
Topics
  • Alkynes (isolation & purification, pharmacology)
  • Animals
  • Anisoles (isolation & purification, pharmacology)
  • Anti-Inflammatory Agents (isolation & purification, pharmacology)
  • Base Sequence
  • Basidiomycota (chemistry)
  • DNA Primers
  • Fruiting Bodies, Fungal (chemistry)
  • Mice
  • Mice, Inbred ICR
  • Reverse Transcriptase Polymerase Chain Reaction

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