Abstract | BACKGROUND: Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi- ultrafine particles <or= 0.25 microm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin. OBJECTIVES: We reassessed biomarker associations with PM0.25 using new particle composition data. METHODS: RESULTS: Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes ( vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not. sTNF-RII increased by 135 pg/mL [95% confidence interval (CI), 45-225 pg/mL], and IL-6 increased by 0.27 pg/mL (95% CI, 0.10-0.44 pg/mL) per interquartile range increase of 0.56 ng/m3 outdoor total PAHs. Two- pollutant models of PM0.25 with PAHs showed that nominal associations of IL-6 and sTNF-RII with PM0.25 mass were completely confounded by PAHs. Vehicular emission sources estimated from chemical mass balance models were strongly correlated with PAHs (R = 0.71). CONCLUSIONS:
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Authors | Ralph J Delfino, Norbert Staimer, Thomas Tjoa, Mohammad Arhami, Andrea Polidori, Daniel L Gillen, Michael T Kleinman, James J Schauer, Constantinos Sioutas |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 118
Issue 6
Pg. 756-62
(Jun 2010)
ISSN: 1552-9924 [Electronic] United States |
PMID | 20123637
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Biomarkers
- Interleukin-6
- Particulate Matter
- Polycyclic Aromatic Hydrocarbons
- Receptors, Tumor Necrosis Factor, Type II
- Triterpenes
- Vehicle Emissions
- hopane
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Topics |
- Aged
- Aged, 80 and over
- Analysis of Variance
- Biomarkers
(blood)
- Environmental Exposure
(analysis)
- Female
- Humans
- Inflammation
(blood, diagnosis)
- Interleukin-6
(blood)
- Longitudinal Studies
- Los Angeles
- Male
- Particle Size
- Particulate Matter
(analysis)
- Polycyclic Aromatic Hydrocarbons
(analysis)
- Receptors, Tumor Necrosis Factor, Type II
(blood)
- Triterpenes
(analysis)
- Vehicle Emissions
(analysis)
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