Forty of eighty mice (10 each group) were infected with S. mansoni cercariae and sacrificed at 3 weeks (G-A), 6 weeks (G-B), 12 weeks (G-C) and 16 weeks (G-D) post
infection (P.I). The other forty mice were used as control groups of ten mice each. There were highly significant difference between egg counts after 12 weeks & 16 weeks of
infection compared to 6 weeks P.I. The maximum egg count and mature eggs were in 6th week P.I while dead eggs reached the peak at 16th weeks P.I. Liver egg counts showed maximum followed by intestinal and then, stool egg counts. A highly significant differences in
hydroxyproline, TGF-Bland
IL-4 of infected than in controls and their peak at 16 weeks P.I. A significant difference in the IFN-gamma in the infected than in controls with peak occurred at 6 weeks P.I. and declined after that reaching a low level at 16 weeks P.I. A highly significant positive correlation was between TGF-Bland
IL4 and significant negative correlation between IFN-gamma and both
IL4 & TGF-B1. A highly significant and significant negative correlation between TGF-B1 and egg count at 12 & 16 weeks P.I respectively. Negative correlation was between
IL-4 and egg count at 16 weeks P.I. But, significant positive correlation was between IFN-gamma with the egg count at 16 weeks P.I. A significant negative correlation was between TGF-B1 and oogram at 6 & 16 weeks P.I, but highly significant positivity was between IFN-gamma and oogram at 16 weeks P.I. A significant negative correlation was between
IL-4 and oogram at 16 weeks P.I. A significant positive correlation was between levels of
hydroxyproline and TGF-B1 at 12 & 16 weeks P.I. Highly significant negative correlation between
hydroxyproline and IFN-gamma was at 12 weeks P.I with significant and highly significant positive correlation between
hydroxyproline and
IL4 at 12 & 16 weeks P.I.