Acute necrotizing encephalopathy secondary to diphtheria, tetanus toxoid and whole-cell pertussis vaccination: diffusion-weighted imaging and proton MR spectroscopy findings.

Abstract	We present a previously healthy 6-month-old boy who was admitted to our hospital with lethargy, hypotonia and focal clonic seizures 6 days following diptheria, tetanus toxoid and whole-cell pertussis vaccination. A diagnosis of acute necrotising encephalopathy was made with the aid of MRI, including diffusion-weighted imaging and proton MR spectroscopy.
Authors	Hale Aydin, Esra Ozgul, Ahmet Muhtesem Agildere
Journal	Pediatric radiology (Pediatr Radiol) Vol. 40 Issue 7 Pg. 1281-4 (Jul 2010) ISSN: 1432-1998 [Electronic] Germany
PMID	20119724 (Publication Type: Case Reports, Journal Article)
Chemical References	Pertussis Vaccine Tetanus Toxin Tetanus Toxoid
Topics	Brain (drug effects, pathology) Diffusion Magnetic Resonance Imaging (methods) Diphtheria (complications) Humans Infant Leukoencephalitis, Acute Hemorrhagic (chemically induced, diagnosis) Magnetic Resonance Spectroscopy (methods) Male Pertussis Vaccine (adverse effects) Tetanus Toxin Tetanus Toxoid (adverse effects)

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