Transient effectiveness of vitamin D2 therapy in pediatric cystic fibrosis patients.

Abstract

BACKGROUND:

The effectiveness of current treatment recommendations for vitamin D insufficiency in children with CF is unknown. Therefore, we assessed the effectiveness of vitamin D(2) 50,000 IU once daily for 28 days for vitamin D insufficiency.

METHODS:

Retrospective chart review of pediatric CF patients from 2006-2008. Vitamin D(2) 50,000 IU daily for 28 days was given to patients with 25-OHD <30 ng/mL and repeat 25-OHD levels were obtained after completion of therapy.

RESULTS:

One hundred forty-seven levels from 97 individuals were assessed. Success of treatment was 54% (n=80/147). Seventeen of 39 patients (43%) followed for an additional 6-18 months were able to maintain levels of >or=30 ng/mL.

CONCLUSIONS:

Vitamin D(2) 50,000 IU daily for 28 days was effective in correcting vitamin D insufficiency in approximately 50% of subjects. However, almost half of successfully treated patients were unable to maintain normal 25-OHD levels >6 months after completion of therapy, implying that this effect is transient.

• Authors: Deanna M Green, Amanda R Leonard, Shruti M Paranjape, Beryl J Rosenstein, Pamela L Zeitlin, Peter J Mogayzel Jr
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 9 Issue 2 Pg. 143-9 (Mar 2010) ISSN: 1873-5010 [Electronic] Netherlands
• PMID: 20117062 (Publication Type: Journal Article)
• Copyright: Copyright (c) 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Ergocalciferols
• Vitamins
• 25-Hydroxyvitamin D 2
• Calcifediol

Topics

• 25-Hydroxyvitamin D 2 (blood)
• Adolescent
• Calcifediol (blood)
• Child
• Child, Preschool
• Cystic Fibrosis (complications)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Ergocalciferols (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Male
• Prevalence
• Retrospective Studies
• Seasons
• Time Factors
• Treatment Outcome
• Vitamin D Deficiency (blood, complications, drug therapy, epidemiology)
• Vitamins (administration & dosage)