[Molecular epidemiology of rotavirus among children under 5 years old hospitalized for diarrhea in China].

Abstract

OBJECTIVE:

To study molecular epidemiology of Rotavirus among children under 5 years of age in china.

METHODS:

Stool specimens were collected from 4047 inpatients under 5 years of age with diarrhea in our 9 hospital-based surveillance sites from January 2006 to December 2007 following the WHO Rotavirus surveillance protocol. Rotavirus were detected by ELISA, Further strain characterization of rotavirus was carried out with RT-PCR.

RESULTS:

A total of 4047 stool samples were collected and 3862 of total stools were tested among which 1700 was positive. The Rotavirus positive rate is 44.0%. A peak admission of rotavirus diarrhea was observed from November to next January. More than 95.4% of viral diarrhea patients occurred in their first 2 years. The incidence rates of rotavirus diarrhea were highest in 12-17 months of age. The most common rotavirus strain was P[8]G3(58.3%); followed by P[8] G1(22.1%), P[4]G1 (3.0%), P[8]G9 (2.4%). G4 was not detected in this study. The four common strains were 80.8% in the world.

CONCLUSION:

Rotavirus diarrhea was an important infectious disease among children under 5 years of age in China. Safe and effective rotavirus vaccines for the prevention of rotavirus diarrhea and reduction of treatment costs are of significant importance to China.

• Authors: Su-Hu Yang, Hong Wang, Na Liu, Qing Zhang, Shu-Xian Cui, Dan-Di Li, Miao Jin, Qing Chen, Zhao-Jun Duan
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 23 Issue 3 Pg. 168-70 (Jun 2009) ISSN: 1003-9279 [Print] China
• PMID: 20104767 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Child, Hospitalized
• Child, Preschool
• China (epidemiology)
• Diarrhea (epidemiology, therapy, virology)
• Feces (virology)
• Female
• Humans
• Infant
• Male
• Molecular Epidemiology
• Molecular Sequence Data
• Rotavirus (classification, genetics, isolation & purification)
• Rotavirus Infections (epidemiology, therapy, virology)
• Seasons