N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats.

Abstract

N-ethylmaleimide (NEM) 10 or 25 mg/kg b.wt, given s.c. 20 min beforehand, dose-dependently and significantly antagonizes the severity of gastric glandular ulcers produced by restraint at 4 degrees C (stress) for 2 h. These findings suggest that reduced activity of endogenous nonprotein sulfhydryl substances in gastric tissue does not worsen stress-induced ulceration in rat stomachs, unlike the deleterious effect its depletion is claimed to have on ethanol-evoked gastric mucosal damage. Thus, decreased SH activity appears not to play a role in the aetiology of mucosal ulcers due to stress.

• Authors: G P Garg, C H Cho, C W Ogle
• Journal: Experientia (Experientia) Vol. 47 Issue 3 Pg. 250-1 (Mar 15 1991) ISSN: 0014-4754 [Print] Switzerland
• PMID: 2009933 (Publication Type: Journal Article)

Chemical References

• Ethylmaleimide

Topics

• Animals
• Cold Temperature
• Ethylmaleimide (pharmacology)
• Female
• Immobilization
• Rats
• Rats, Inbred Strains
• Stomach Ulcer (etiology, physiopathology)
• Stress, Physiological