Evaluation of patients with Clinically Unclear Parkinsonian Syndromes submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1.

Abstract

Despite its relatively high prevalence Parkinson's Disease (PD) is still misdiagnosed in approximately 25% of cases. In this study our aim was to evaluate patients with Clinically Unclear Parkinsonian Syndromes (CUPS) submitted to brain SPECT imaging using the technetium-99m labeled Dopamine Transporter (DAT) tracer TRODAT-1. We recruited 15 subjects with CUPS and matched them with 13 patients with probable PD and 13 healthy control subjects (HCS). A SPECT with TRODAT-1 was performed at the baseline evaluation and patients from the CUPS were followed-up for 2-years to ensure or not PD diagnosis ("gold-standard"). The mean+/-SD results from Right and Left striatum Binding Potential (BP) were, respectively, 1.08+/-0.20 and 1.04+/-0.16 in the HCS group, 0.47+/-0.16 and 0.53+/-0.17 in the PD group, and 0.68+/-0.11 and 0.84+/-0.17 in the CUPS group. The rate of disagreement between baseline SPECT in the CUPS group as compared to the "gold standard" diagnosis (clinical diagnosis of PD on follow-up) was of 20%. The sensitivity of the SPECT with TRODAT-1 was 100%, while specificity was 70%. In conclusion, our data provided further information about the role of the technetium-99m labeled tracer TRODAT-1 as a biomarker of DAT reduction that can also be used in the diagnosis of patients with CUPS.

• Authors: Andre C Felicio, Clecio Godeiro-Junior, Ming C Shih, Vanderci Borges, Sônia M A Silva, Patrícia de Carvalho Aguiar, Marcelo Q Hoexter, Orlando G P Barsottini, Luiz A F Andrade, Rodrigo A Bressan, Henrique B Ferraz
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 291 Issue 1-2 Pg. 64-8 (Apr 15 2010) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 20096859 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier B.V. All rights reserved.

Chemical References

• Organotechnetium Compounds
• Tropanes
• technetium Tc 99m TRODAT-1

Topics

• Brain (diagnostic imaging)
• Corpus Striatum (diagnostic imaging)
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Functional Laterality
• Humans
• Male
• Middle Aged
• Organotechnetium Compounds
• Parkinson Disease (diagnosis, diagnostic imaging)
• Parkinsonian Disorders (diagnosis, diagnostic imaging)
• Sensitivity and Specificity
• Tomography, Emission-Computed, Single-Photon
• Tropanes