HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers?

Abstract
Despite recent advancements in treatment modalities, the overall survival and quality of life of patients with head and neck squamous cell carcinoma (HNSCC) have not improved significantly over the past decade. With the increasing emergency of new biological agents, the development of novel treatment schemes based on cancer cell biology may be promising for this group of patients. We previously introduced the "oncogene addiction" concept as a rationale for molecular targeting in cancer therapy and prevention. In this context, an increasing number of preclinical studies have demonstrated that the Signal Transducers and Activators of transcription 3 (Stat3) transcription factor plays critical roles in the development and progression of a variety of tumors including HNSCC, by regulating cell proliferation, cell cycle progression, apoptosis, angiogenesis, immune evasion, Epithelial-Mesenchymal Transition (EMT) and through effects in cancer stem cells. The purpose of this review is to summarize current experimental and clinical evidence that suggest that HNSCC might be addicted to Stat3 and describe the molecular mechanisms that may explain this phenomenon. In addition, we discuss whether this addiction is an exploitable target for developing approaches for the treatment and prevention of HNSCC.
AuthorsMuneyuk Masuda, T Wakasaki, Masumi Suzui, Satoshi Toh, Andrew K Joe, I B Weinstein
JournalCurrent cancer drug targets (Curr Cancer Drug Targets) Vol. 10 Issue 1 Pg. 117-26 (Feb 2010) ISSN: 1873-5576 [Electronic] Netherlands
PMID20088788 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Proto-Oncogene Proteins c-bcl-2
  • STAT3 Transcription Factor
Topics
  • Animals
  • Apoptosis
  • Cell Proliferation
  • Cell Transformation, Neoplastic (pathology)
  • Drug Resistance, Neoplasm
  • Head and Neck Neoplasms (drug therapy, metabolism, pathology)
  • Humans
  • Mice
  • Neoplasms, Squamous Cell (drug therapy, metabolism, pathology)
  • Neovascularization, Pathologic (drug therapy, pathology)
  • Proto-Oncogene Proteins c-bcl-2 (metabolism)
  • STAT3 Transcription Factor (agonists, antagonists & inhibitors, metabolism)
  • Tumor Escape

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: