Abstract | BACKGROUND: METHODS: Fifty adult male patients were randomly assigned to receive either epidural dexmedetomidine 1 microg/kg with bupivacaine 0.5% (group D) or bupivacaine 0.5% alone (group B) after induction of general anaesthesia. Gasometric, haemodynamic and bispectral index values were recorded. Post-operative verbal rating score for pain and observer's assessment of alertness/sedation scale were determined by a blinded observer. RESULTS:
Dexmedetomidine reduced the use of supplementary fentanyl during surgery. Patients in group B consumed more analgesics and had higher pain scores after operation than patients of group D. The level of sedation was similar between the two groups in the ICU. Two patients (8%) in group B reported possible intraoperative awareness. There was a limited decrease in PaO2 at OLV in group D compared with group B (P<0.05). CONCLUSION: In thoracic surgery with OLV, the use of epidural dexmedetomidine decreases the anaesthetic requirements significantly, prevents awareness during anaesthesia and improves intraoperative oxygenation and post-operative analgesia.
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Authors | M Elhakim, D Abdelhamid, H Abdelfattach, H Magdy, A Elsayed, M Elshafei |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 54
Issue 6
Pg. 703-9
(Jul 2010)
ISSN: 1399-6576 [Electronic] England |
PMID | 20085547
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-Agonists
- Analgesics, Non-Narcotic
- Anesthetics, Inhalation
- Hypnotics and Sedatives
- Dexmedetomidine
- Isoflurane
- Bupivacaine
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage, pharmacology, therapeutic use)
- Adult
- Analgesics, Non-Narcotic
(administration & dosage, pharmacology, therapeutic use)
- Anesthesia, Epidural
- Anesthesia, General
- Anesthetics, Inhalation
(administration & dosage, adverse effects, pharmacology)
- Awareness
(drug effects)
- Bupivacaine
(administration & dosage)
- Consciousness Monitors
- Dexmedetomidine
(administration & dosage, pharmacology, therapeutic use)
- Hemodynamics
(drug effects)
- Humans
- Hypnotics and Sedatives
(administration & dosage, pharmacology, therapeutic use)
- Hypoxia
(chemically induced, prevention & control)
- Intraoperative Complications
(epidemiology, prevention & control)
- Isoflurane
(administration & dosage, adverse effects, pharmacology)
- Male
- Middle Aged
- Pain, Postoperative
(drug therapy, prevention & control)
- Respiration, Artificial
(methods)
- Single-Blind Method
- Thoracic Surgical Procedures
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