The use of AlloDerm on major burn patients: AlloDerm prevents post-burn joint contracture.

Abstract

In efforts to prevent and reduce joint contracture and scar formation after burn, we used the acellular human dermis (AlloDerm) as a dermal replacement in the acute stage. A total of 64 patients received AlloDerm graft selectively on joint areas during the study period from March, 2005 to July, 2007. From January to March, 2008, a total of 31 patients returned to our burn center to examine the functional results by measuring range of motion of joints. Additionally, the quality of grafted skin condition criteria of skin elasticity, scar thickness, trans-epidermal water loss, melanin and erythema level was measured in a total of 11 patients among them. By analyzing the limitation level of 55 joints excluding hand areas, we found that 24 joints (43.6%) showed no limitations, 12 joints (21.8%) showed limitations below 10%, 16 joints (29.1%) showed limitations between 10 and 19% and 3 joints (5.5%) showed limitations over 20%. The scar thickness of non-AlloDerm applied areas was 2.5+/-0.9 mm and AlloDerm applied areas was 1.8+/-0.7 mm (p = 0.396). Trans-epidermal water loss for non-AlloDerm applied areas was 20.9+/-7.7 g/h/m(2) and AlloDerm applied areas was 10.8+/-3.4 g/h/m(2) (p<0.001). Erythema value for non-AlloDerm applied areas was 436.1+/-65.8, whereas AlloDerm applied area was 394.4+/-61.2 (p<0.001). Acellular dermal matrix is a good option for treating major burns to prevent scar formation after burn and loss of joint function.

• Authors: Haejun Yim, Yong Suk Cho, Cheong Hoon Seo, Boung Chul Lee, Jang Hyu Ko, Dohern Kim, Jun Hur, Wook Chun, Jong Hyun Kim
• Journal: Burns : journal of the International Society for Burn Injuries (Burns) Vol. 36 Issue 3 Pg. 322-8 (May 2010) ISSN: 1879-1409 [Electronic] Netherlands
• PMID: 20080353 (Publication Type: Evaluation Study, Journal Article)
• Copyright: Copyright 2009 Elsevier Ltd and ISBI. All rights reserved.

Chemical References

• Alloderm
• Biocompatible Materials
• Collagen

Topics

• Adolescent
• Adult
• Biocompatible Materials
• Burns (complications, physiopathology, surgery)
• Child
• Child, Preschool
• Cicatrix (pathology, physiopathology)
• Collagen (therapeutic use)
• Contracture (etiology, physiopathology, prevention & control)
• Elasticity
• Female
• Humans
• Male
• Middle Aged
• Range of Motion, Articular
• Skin Transplantation (methods)
• Skin, Artificial
• Water Loss, Insensible