Abstract | BACKGROUND: METHODS: Using quantitative polymerase chain reaction, we quantified transcripts for VGluT1, netrin-G1 ( isoforms G1c, G1d, and G1f), and netrin-G2 in the anterior cingulate cortex from subjects with bipolar disorder (n = 34), schizophrenia (n = 35), and healthy control subjects (n = 35). RESULTS: CONCLUSIONS: Increased VGluT1 expression is supportive of elevated glutamate neurotransmission in the anterior cingulate cortex in bipolar disorder. The netrin-G1 and netrin-G2 findings suggest there may be an underlying difference in the plasticity of the affected circuitry.
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Authors | Sharon L Eastwood, Paul J Harrison |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 67
Issue 11
Pg. 1010-6
(Jun 01 2010)
ISSN: 1873-2402 [Electronic] United States |
PMID | 20079890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- GPI-Linked Proteins
- Glycoproteins
- NTNG2 protein, human
- Nerve Tissue Proteins
- Netrins
- Vesicular Glutamate Transport Protein 1
- netrin-G1
- Glutamic Acid
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Topics |
- Adult
- Aged
- Analysis of Variance
- Bipolar Disorder
(genetics, metabolism)
- Female
- Functional Laterality
(physiology)
- GPI-Linked Proteins
- Genotype
- Glutamic Acid
(genetics, metabolism)
- Glycoproteins
(genetics, metabolism)
- Gyrus Cinguli
(metabolism)
- Humans
- In Situ Hybridization
- Male
- Middle Aged
- Nerve Tissue Proteins
(genetics, metabolism)
- Netrins
- Neuronal Plasticity
(physiology)
- Neurons
(metabolism)
- Presynaptic Terminals
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Schizophrenia
(genetics, metabolism)
- Synaptic Transmission
(physiology)
- Vesicular Glutamate Transport Protein 1
(genetics, metabolism)
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