Abstract | OBJECTIVE: To evaluate whether measuring cell-free placental mRNA in maternal plasma improves the diagnostic accuracy of ultrasound and color Doppler in detecting placental invasion in patients at risk for placenta accreta. METHODS: Thirty-five singleton pregnant women of more than 28 weeks of gestation and at risk for placenta accreta underwent ultrasound and color Doppler assessment. Cell-free placental mRNA in maternal plasma was measured using real-time reverse-transcription polymerase chain reaction. Patients were classified into 2 groups based on the findings at cesarean delivery and histological examination: women with placenta accreta (n=7) and women without placenta accreta (n=28). RESULTS: The median MoM (multiples of the median) value of cell-free placental mRNA was significantly higher in patients with placenta accreta than in those without placenta accreta (6.50 vs 2.60; P<0.001. Moreover, cell-free placental mRNA was significantly elevated in patients with placenta increta and percreta than in those with simple accreta. Six false-positive results were found on ultrasound, all from patients without placenta accreta and an insignificant rise in cell-free placental mRNA levels. CONCLUSION: Measuring cell-free placental mRNA in maternal plasma may increase the accuracy of ultrasound and color Doppler in prenatal prediction of placental invasion in patients with suspected placenta accreta.
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Authors | Manal M El Behery, Etewa Rasha L, Yehya El Alfy |
Journal | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
(Int J Gynaecol Obstet)
Vol. 109
Issue 1
Pg. 30-3
(Apr 2010)
ISSN: 1879-3479 [Electronic] United States |
PMID | 20070963
(Publication Type: Journal Article)
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Copyright | Copyright 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- RNA, Messenger
|
Topics |
- Adult
- Biomarkers
(blood)
- Female
- Humans
- Placenta Accreta
(blood, diagnostic imaging)
- Pregnancy
- Prospective Studies
- RNA, Messenger
(blood)
- Ultrasonography, Doppler, Color
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