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Cell-free placental mRNA in maternal plasma to predict placental invasion in patients with placenta accreta.

AbstractOBJECTIVE:
To evaluate whether measuring cell-free placental mRNA in maternal plasma improves the diagnostic accuracy of ultrasound and color Doppler in detecting placental invasion in patients at risk for placenta accreta.
METHODS:
Thirty-five singleton pregnant women of more than 28 weeks of gestation and at risk for placenta accreta underwent ultrasound and color Doppler assessment. Cell-free placental mRNA in maternal plasma was measured using real-time reverse-transcription polymerase chain reaction. Patients were classified into 2 groups based on the findings at cesarean delivery and histological examination: women with placenta accreta (n=7) and women without placenta accreta (n=28).
RESULTS:
The median MoM (multiples of the median) value of cell-free placental mRNA was significantly higher in patients with placenta accreta than in those without placenta accreta (6.50 vs 2.60; P<0.001. Moreover, cell-free placental mRNA was significantly elevated in patients with placenta increta and percreta than in those with simple accreta. Six false-positive results were found on ultrasound, all from patients without placenta accreta and an insignificant rise in cell-free placental mRNA levels.
CONCLUSION:
Measuring cell-free placental mRNA in maternal plasma may increase the accuracy of ultrasound and color Doppler in prenatal prediction of placental invasion in patients with suspected placenta accreta.
AuthorsManal M El Behery, Etewa Rasha L, Yehya El Alfy
JournalInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 109 Issue 1 Pg. 30-3 (Apr 2010) ISSN: 1879-3479 [Electronic] United States
PMID20070963 (Publication Type: Journal Article)
CopyrightCopyright 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Biomarkers
  • RNA, Messenger
Topics
  • Adult
  • Biomarkers (blood)
  • Female
  • Humans
  • Placenta Accreta (blood, diagnostic imaging)
  • Pregnancy
  • Prospective Studies
  • RNA, Messenger (blood)
  • Ultrasonography, Doppler, Color

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