Abstract | PURPOSE: METHODS: Male Sprague-Dawley rats were divided into the following groups: Healthy/Placebo, Healthy/ Statin, Pre-AA/Placebo, and Pre-AA/ Statin (n=7-8/group). On Day 0, to the Pre-AA and Healthy groups, was injected Mycobacterium butyricum or saline, respectively. On Days 4-8, Statin and Placebo groups received either pravastatin (6 mg/kg) or placebo twice daily, respectively. On day 8, heart and blood samples were collected. The density of NET and 1-AR in heart homogenate; NE in plasma and heart and inflammatory mediators ( nitrite and interferon-gamma) in serum were determined. RESULTS:
Inflammation was associated with a significant reduction in both beta1-AR and NET density with a positive correlation between the two proteins (r=0.978, p<0.0001). The down-regulating effect of inflammation was not reversed by pravastatin. Inflammation had no significant effect on the plasma or heart NE concentration. CONCLUSION: The close relations of NET and beta1-AR implicates altered sympathetic innervation and/or local NE handling in pharmacotherapeutic desensitization observed in arthritis.
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Authors | John D Clements, Fakhreddin Jamali |
Journal | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
(J Pharm Pharm Sci)
Vol. 12
Issue 3
Pg. 337-45
( 2009)
ISSN: 1482-1826 [Electronic] Canada |
PMID | 20067708
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Inflammation Mediators
- Nitrites
- Norepinephrine Plasma Membrane Transport Proteins
- Receptors, Adrenergic, beta-1
- Interferon-gamma
- Pravastatin
- Norepinephrine
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Topics |
- Animals
- Arthritis, Experimental
(metabolism)
- Blotting, Western
- Down-Regulation
- Heart
(drug effects)
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Inflammation Mediators
(blood)
- Interferon-gamma
(blood)
- Male
- Myocardium
(metabolism)
- Nitrites
(blood)
- Norepinephrine
(blood, metabolism)
- Norepinephrine Plasma Membrane Transport Proteins
(metabolism)
- Pravastatin
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Adrenergic, beta-1
(metabolism)
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