Abstract | OBJECTIVE: METHODS: RESULTS: A 56-year-old woman presented with rapid development of virilization, cushingoid features, hypertension, weight gain, and abdominal distension. An 8-cm left adrenal lesion was found on computed tomography, removed surgically, and confirmed as adrenal carcinoma on pathologic examination. Postoperative scanning revealed metastases to both lungs and the liver that were confirmed by fine-needle biopsy, thus establishing stage IV disease. Treatment with the adrenolytic agent mitotane failed to halt disease progression. A trial of sorafenib resulted in regression and eventual resolution of bilateral metastatic lung lesions, reduction in size of the hepatic lesion, normalization of androgen hypersecretion, and marked clinical improvement. The radiologic and biochemical remission on sorafenib has continued for 28 months. CONCLUSION:
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Authors | Charles Butler, William M Butler, Ali A Rizvi |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
2010 May-Jun
Vol. 16
Issue 3
Pg. 441-5
ISSN: 1934-2403 [Electronic] United States |
PMID | 20061282
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Benzenesulfonates
- Phenylurea Compounds
- Protein Kinase Inhibitors
- Pyridines
- Niacinamide
- Sorafenib
|
Topics |
- Adrenocortical Carcinoma
(pathology, secondary)
- Benzenesulfonates
(therapeutic use)
- Female
- Humans
- Middle Aged
- Niacinamide
(analogs & derivatives)
- Phenylurea Compounds
- Protein Kinase Inhibitors
(therapeutic use)
- Pyridines
(therapeutic use)
- Sorafenib
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