Abstract | AIMS: METHODS: Seventeen patients with infantile spasms, who were admitted to our hospital between October 2005 and November 2007, were eligible for enrollment within two months of diagnosis. Zonisamide was administered at a starting dose of 2-8 mg/kg/day, increasing by 2-5 mg/kg/day every three to four days until the seizures disappeared or the dose reached 30 mg/kg/day. Complete response was defined as clinical cessation of infantile spasms over 28 consecutive days and disappearance of hypsarrhythmia by EEG analysis. RESULTS: Of the 17 treated patients (nine who received initial monotherapy and eight add-on therapy), five of 12 (42.0%) cryptogenic patients and two of five (40.0%) symptomatic patients showed complete disappearance of spasms. The maximum daily dose was 10-28 mg/kg, and the effective daily dose was 10-22 mg/kg. Mean time period before disappearance of spasms and hypsarrhythmia was eight days. Seizure recurrence was observed in three of the seven patients who showed complete disappearance of spasms. Adverse effects included irritability in four patients and poor oral intake in two patients. CONCLUSION:
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Authors | Mi-Sun Yum, Tae-Sung Ko |
Journal | Epileptic disorders : international epilepsy journal with videotape
(Epileptic Disord)
Vol. 11
Issue 4
Pg. 339-44
(Dec 2009)
ISSN: 1294-9361 [Print] France |
PMID | 20045779
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Isoxazoles
- Zonisamide
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Topics |
- Age of Onset
- Anticonvulsants
(therapeutic use)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Infant
- Isoxazoles
(therapeutic use)
- Male
- Spasms, Infantile
(drug therapy)
- Zonisamide
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