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[Extracorporeal photochemotherapy].

Abstract
Photopheresis or extracorporeal photochemotherapy (ECP) is a cellular therapy which combines a leukapheresis followed by ex vivo treatment using psoralen and ultraviolet A irradiation before reinfusion into the patient. Its mechanisms of action remain unclear and selective photodestruction of leukocytes cannot explain the long-lasting immunomodulatory effects. Recent studies demonstrated that ECP down regulates the immune response and induces tolerance through the maturation of dendritic cells and the production of regulatory T cells. Based on these effects, ECP is mainly used for treatment of Sezary syndrome, graft-versus-host disease, organ graft rejection and autoimmune diseases. However, it is still not clear how ECP both activates tumor immunity against cutaneous T-cell lymphoma and induces tolerance in autoreactive disorders. In addition, the use of adjuvant therapies, the long-term effects and various treatment protocols remain to be investigated along with the specific indications.
AuthorsM Viguier, F Pouthier, P Tiberghien, F Aubin
JournalTransfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine (Transfus Clin Biol) Vol. 17 Issue 1 Pg. 28-33 (Feb 2010) ISSN: 1953-8022 [Electronic] France
Vernacular TitleLa photochimiothérapie extracorporelle.
PMID20042357 (Publication Type: Journal Article, Review)
Topics
  • Autoimmune Diseases (drug therapy)
  • Dendritic Cells (drug effects, immunology)
  • Fever (etiology)
  • Graft Rejection (prevention & control)
  • Graft vs Host Disease (drug therapy)
  • Humans
  • Hypotension (etiology)
  • Immune Tolerance (immunology)
  • Immunosuppression Therapy (methods)
  • Lymphoma, T-Cell, Cutaneous (drug therapy)
  • Photopheresis (adverse effects, methods)
  • Social Control, Formal
  • T-Lymphocytes, Regulatory (immunology)

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