Abstract |
Photopheresis or extracorporeal photochemotherapy (ECP) is a cellular therapy which combines a leukapheresis followed by ex vivo treatment using psoralen and ultraviolet A irradiation before reinfusion into the patient. Its mechanisms of action remain unclear and selective photodestruction of leukocytes cannot explain the long-lasting immunomodulatory effects. Recent studies demonstrated that ECP down regulates the immune response and induces tolerance through the maturation of dendritic cells and the production of regulatory T cells. Based on these effects, ECP is mainly used for treatment of Sezary syndrome, graft-versus-host disease, organ graft rejection and autoimmune diseases. However, it is still not clear how ECP both activates tumor immunity against cutaneous T-cell lymphoma and induces tolerance in autoreactive disorders. In addition, the use of adjuvant therapies, the long-term effects and various treatment protocols remain to be investigated along with the specific indications.
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Authors | M Viguier, F Pouthier, P Tiberghien, F Aubin |
Journal | Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
(Transfus Clin Biol)
Vol. 17
Issue 1
Pg. 28-33
(Feb 2010)
ISSN: 1953-8022 [Electronic] France |
Vernacular Title | La photochimiothérapie extracorporelle. |
PMID | 20042357
(Publication Type: Journal Article, Review)
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Topics |
- Autoimmune Diseases
(drug therapy)
- Dendritic Cells
(drug effects, immunology)
- Fever
(etiology)
- Graft Rejection
(prevention & control)
- Graft vs Host Disease
(drug therapy)
- Humans
- Hypotension
(etiology)
- Immune Tolerance
(immunology)
- Immunosuppression Therapy
(methods)
- Lymphoma, T-Cell, Cutaneous
(drug therapy)
- Photopheresis
(adverse effects, methods)
- Social Control, Formal
- T-Lymphocytes, Regulatory
(immunology)
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