Abstract | AIM: METHOD: We reviewed the four cases retrospectively and we also reviewed the literature. RESULTS: INTERPRETATION: The clinical features are similar to those first reported in 1992 by Sebire et al.,(1) and rarely recognized since. Sleep disturbance was not emphasized as part of the disorder, but appears to be an important feature, whereas coma is less certain and difficult to evaluate in this setting. The combination of symptoms, evolution (mainly seizures at onset), severity, paucity of abnormal laboratory findings, very slow recovery, and difficult management justify its recognition as a specific entity. The neuropathological substrate may be anatomically close to that involved in encephalitis lethargica, in which the same target functions (sleep and movement) are affected but in reverse, with hypersomnolence and bradykinesia. This syndrome closely resembles anti-NMDA receptor encephalitis, which has been reported in adults and is often paraneoplastic.
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Authors | Claudia Poloni, Christian M Korff, Valeria Ricotti, Mary D King, Eliane Roulet Perez, Claire Mayor-Dubois, Charles-Antoine Haenggeli, Thierry Deonna |
Journal | Developmental medicine and child neurology
(Dev Med Child Neurol)
Vol. 52
Issue 5
Pg. e78-82
(May 2010)
ISSN: 1469-8749 [Electronic] England |
PMID | 20041934
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Autoantibodies
- Receptors, N-Methyl-D-Aspartate
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Topics |
- Autoantibodies
(blood)
- Brain
(pathology, physiopathology)
- Child
- Child, Preschool
- Cognition Disorders
(etiology, physiopathology)
- Dyskinesias
(etiology, physiopathology)
- Electroencephalography
- Encephalitis
(complications, diagnosis, immunology, pathology, physiopathology)
- Female
- Humans
- Magnetic Resonance Imaging
- Mutism
(etiology)
- Prognosis
- Receptors, N-Methyl-D-Aspartate
(immunology)
- Retrospective Studies
- Severity of Illness Index
- Sleep Wake Disorders
(etiology, physiopathology)
- Time Factors
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