Abstract |
We examined the beneficial effects of an active principle in kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid ( HDMPPA), on atherogenesis in apolipoprotein E knockout ( apoE KO) mice. ApoE KO mice were fed an atherogenic diet containing 1% cholesterol (control group) with an intraperitoneal injection of chemically synthesized HDMPPA (10 mg/kg/day) ( HDMPPA group) for 8 weeks. The aortic sinus atherosclerotic lesion size in the HDMPPA group (n = 10) was significantly smaller (control vs. HDMPPA, 280,790 vs. 165,409 microm(2), P < .001). The level of reactive oxygen species (ROS) in the HDMPPA group was lower by 14%, compared with the control group (P < .05). Aortic NADPH oxidase activity was significantly lower in the HDMPPA group than in the control group. HDMPPA suppressed the mRNA expression of p47phox and rac-1 of NADPH oxidase by 27.2% and 46.0%, respectively, compared with values of the control group. In conclusion, HDMPPA in kimchi may attenuate atherosclerosis in apoE KO mice through retardation of ROS generation via down-regulating the mRNA expression of p47phox and rac-1, which are the components of NADPH oxidase.
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Authors | Jeong Sook Noh, Hyun Ju Kim, Myung Ja Kwon, Yeong Ok Song |
Journal | Journal of medicinal food
(J Med Food)
Vol. 12
Issue 6
Pg. 1206-12
(Dec 2009)
ISSN: 1557-7600 [Electronic] United States |
PMID | 20041773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid
- Apolipoproteins E
- Lipids
- Phenyl Ethers
- Plant Extracts
- Propionates
- Reactive Oxygen Species
- NADPH Oxidases
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Topics |
- Animals
- Apolipoproteins E
(genetics, metabolism)
- Atherosclerosis
(blood, drug therapy, metabolism, pathology)
- Brassica
(chemistry)
- Disease Models, Animal
- Humans
- Lipids
(blood)
- Male
- Mice
- Mice, Knockout
- NADPH Oxidases
(metabolism)
- Phenyl Ethers
- Plant Extracts
(administration & dosage)
- Propionates
(administration & dosage)
- Random Allocation
- Reactive Oxygen Species
(metabolism)
- Sinus of Valsalva
(metabolism, pathology)
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