Abstract | OBJECTIVE: METHODS: We performed detailed neuropathologic examination for 3 individuals with PDD who had PIB PET imaging within 15 months of death. RESULTS: We observed elevated cortical uptake of [( 11)C]-PIB on in vivo PET imaging in 2 of the 3 cases. At autopsy, all 3 individuals had abundant cortical Lewy bodies (Braak PD stage 6), and were classified as low-probability Alzheimer disease (AD) based on NIA-Reagan criteria. The 2 PIB-positive individuals had abundant diffuse Abeta plaques but only sparse neuritic plaques and intermediate neurofibrillary tangle pathology. The PIB-negative individual had rare diffuse plaques, no neuritic plaques, and low neurofibrillary tangle burden. CONCLUSIONS:
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Authors | M A Burack, J Hartlein, H P Flores, L Taylor-Reinwald, J S Perlmutter, N J Cairns |
Journal | Neurology
(Neurology)
Vol. 74
Issue 1
Pg. 77-84
(Jan 05 2010)
ISSN: 1526-632X [Electronic] United States |
PMID | 20038776
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
- Amyloid
- Amyloid beta-Peptides
- Aniline Compounds
- Carbon Radioisotopes
- Thiazoles
- alpha-Synuclein
- tau Proteins
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Topics |
- Amyloid
(metabolism)
- Amyloid beta-Peptides
(metabolism)
- Aniline Compounds
- Autopsy
(methods)
- Brain Mapping
- Carbon Radioisotopes
- Cerebral Cortex
(pathology)
- Dementia
(complications, diagnostic imaging)
- Female
- Humans
- Lewy Bodies
(diagnostic imaging)
- Male
- Mental Status Schedule
- Neurofibrillary Tangles
(diagnostic imaging, pathology)
- Parkinson Disease
(complications, diagnostic imaging)
- Positron-Emission Tomography
(methods)
- Prospective Studies
- Protein Binding
- Severity of Illness Index
- Thiazoles
- alpha-Synuclein
(metabolism)
- tau Proteins
(metabolism)
|