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IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells.

Abstract
Foxp3(+)CD4(+) regulatory T cells (Treg) control not only autoimmunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-alpha in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses.
AuthorsNobuhiko Kubota, Takashi Ebihara, Misako Matsumoto, Satoshi Gando, Tsukasa Seya
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 391 Issue 3 Pg. 1421-6 (Jan 15 2010) ISSN: 1090-2104 [Electronic] United States
PMID20026056 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2009 Elsevier Inc. All rights reserved.
Chemical References
  • Adaptor Proteins, Vesicular Transport
  • Interferon-alpha
  • Interleukin-6
  • RNA, Double-Stranded
  • RNA, Viral
  • TICAM-1 protein, mouse
  • Poly C
Topics
  • Adaptor Proteins, Vesicular Transport (genetics, metabolism)
  • Animals
  • Bone Marrow Cells (cytology, immunology)
  • Cell Proliferation
  • Cells, Cultured
  • Dendritic Cells (immunology)
  • Interferon-alpha (genetics, metabolism)
  • Interleukin-6 (genetics, metabolism)
  • Lymphocyte Activation
  • Mice
  • Mice, Mutant Strains
  • Poly C (immunology, pharmacology)
  • RNA, Double-Stranded (immunology, pharmacology)
  • RNA, Viral (immunology)
  • Rats
  • T-Lymphocytes, Regulatory (drug effects, immunology)

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