Abstract |
Foxp3(+)CD4(+) regulatory T cells (Treg) control not only autoimmunity but also the effective immune response against RNA virus infections, which produces virus-derived double-stranded RNA (dsRNA). To induce effective anti-viral immunity, it is a key issue to learn how Treg respond to dsRNA in vitro and in vivo. We here showed that synthetic dsRNA, polyI:C, caused peripheral expansion of functional Treg in a TICAM-1- and IL-6-dependent manner in vivo. PolyI:C did not expand Treg directly, but promoted the expansion of naturally occurring Treg indirectly through IL-6 produced from dendritic cells (DCs). In addition, the expansion of Treg by IL-6 was inhibited by IFN-alpha from polyI:C-stimulated DCs. These data suggest that the balance of IL-6 and IFN-alpha in the region of RNA virus infection may determine the number of peripheral Treg, which affects the effective immune responses against viruses.
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Authors | Nobuhiko Kubota, Takashi Ebihara, Misako Matsumoto, Satoshi Gando, Tsukasa Seya |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 391
Issue 3
Pg. 1421-6
(Jan 15 2010)
ISSN: 1090-2104 [Electronic] United States |
PMID | 20026056
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 Elsevier Inc. All rights reserved. |
Chemical References |
- Adaptor Proteins, Vesicular Transport
- Interferon-alpha
- Interleukin-6
- RNA, Double-Stranded
- RNA, Viral
- TICAM-1 protein, mouse
- Poly C
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Topics |
- Adaptor Proteins, Vesicular Transport
(genetics, metabolism)
- Animals
- Bone Marrow Cells
(cytology, immunology)
- Cell Proliferation
- Cells, Cultured
- Dendritic Cells
(immunology)
- Interferon-alpha
(genetics, metabolism)
- Interleukin-6
(genetics, metabolism)
- Lymphocyte Activation
- Mice
- Mice, Mutant Strains
- Poly C
(immunology, pharmacology)
- RNA, Double-Stranded
(immunology, pharmacology)
- RNA, Viral
(immunology)
- Rats
- T-Lymphocytes, Regulatory
(drug effects, immunology)
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