Comparative analysis of carmellose 0.5% versus hyaluronate 0.15% in dry eye: a flow cytometric study.

Abstract

PURPOSE:

To compare the effects of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome and to study the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens.

METHODS:

In this randomized, masked-observer, parallel group, single-center study, 15 patients with dry eye syndrome were randomized to sodium carmellose 0.5% or sodium hyaluronate 0.15% 1-month treatment after a 1-week washout period. Corneal staining with flurescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry.

RESULTS:

Carmellose group shows statistical improvement compared with the hyaluronate group in breakup time, corneal staining, and HLA-DR. The two other inflammatory markers had also a tendency for a decreased expression in both groups, with no statistical significance. There were neither visual acuity loss nor other complications related to treatment.

CONCLUSION:

Both artificial tears improve dry eye signs and symptoms and inflammatory markers expression, with significant better results in carmellose group.

• Authors: Miguel Angel Sanchez, Pilar Torralbo-Jimenez, Natalia Giron, Beatriz de la Heras, Rocio Herrero Vanrell, Pedro Arriola-Villalobos, David Diaz-Valle, Alberto Alvarez-Barrientos, Jose M Benitez-Del-Castillo
• Journal: Cornea (Cornea) Vol. 29 Issue 2 Pg. 167-71 (Feb 2010) ISSN: 1536-4798 [Electronic] United States
• PMID: 20023577 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CD11b Antigen
• CD3 Complex
• HLA-DR Antigens
• ITGAM protein, human
• Ophthalmic Solutions
• Hyaluronic Acid
• Carboxymethylcellulose Sodium
• Fluorescein

Topics

• Adult
• Aged
• Biomarkers (metabolism)
• CD11b Antigen (metabolism)
• CD3 Complex (metabolism)
• Carboxymethylcellulose Sodium (administration & dosage)
• Cornea (drug effects, metabolism)
• Double-Blind Method
• Dry Eye Syndromes (drug therapy, metabolism)
• Female
• Flow Cytometry
• Fluorescein (metabolism)
• HLA-DR Antigens (metabolism)
• Humans
• Hyaluronic Acid (administration & dosage)
• Middle Aged
• Ophthalmic Solutions (administration & dosage)
• Prognosis
• Staining and Labeling (methods)
• Tears (chemistry)