Clinicopathologic similarities between Mikulicz disease and Küttner tumor.

Abstract

PURPOSE:

Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. Küttner tumor (KT) is also reported to be an IgG(4)-related disease. In this study, we examined the clinicopathologic and serologic findings in MD (39 patients) and KT (6 patients) and attempted to discern the similarities between MD and KT.

MATERIALS AND METHODS:

We diagnosed 39 patients with MD and 6 patients with KT. We analyzed the clinicopathologic and serologic findings (IgG subclasses) in 39 patients with MD and 6 patients with KT. Submandibular and labial salivary gland specimens obtained from patients with MD and KT were stained with anti-IgG(4) antibodies.

RESULTS:

The mean IgG(4) concentration (±SD) was 931.1 ± 796.2 mg/dL in patients with MD and 756.2 ± 449.2 mg/dL in patients with KT. Abundant infiltration of IgG(4)-positive plasmacytes into the salivary glands was observed in both patients with MD and patients with KT.

CONCLUSION:

The serologic and histopathologic findings in MD and KT are very similar, and these 2 conditions may be IgG(4)-related systemic diseases.

• Authors: Ken-ichi Takano, Motohisa Yamamoto, Hiroki Takahashi, Yasuhisa Shinomura, Kohzoh Imai, Tetsuo Himi
• Journal: American journal of otolaryngology (Am J Otolaryngol) 2010 Nov-Dec Vol. 31 Issue 6 Pg. 429-34 ISSN: 1532-818X [Electronic] United States
• PMID: 20015799 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Immunoglobulin G

Topics

• Adult
• Aged
• Aged, 80 and over
• Diagnosis, Differential
• Female
• Humans
• Immunoglobulin G (analysis)
• Immunohistochemistry
• Male
• Middle Aged
• Mikulicz' Disease (immunology, pathology)
• Plasma Cells (immunology)
• Salivary Glands (immunology)
• Sialadenitis (immunology, pathology)
• Submandibular Gland (immunology)
• Submandibular Gland Diseases (immunology, pathology)