Abstract | OBJECTIVE: To identify and evaluate available data on pediatric echinocandin use. DATA SOURCES: A PubMed search, limited to English-language articles, was conducted (1990-August 2009) using the search terms echinocandin, pediatric, child, pharmacokinetics, caspofungin, micafungin, and anidulafungin. Additional articles were retrieved from citations of selected references. STUDY SELECTION AND DATA EXTRACTION: Relevant information on the pharmacology, pharmacokinetics, efficacy, and safety of echinocandins in children was selected. Clinical trials, retrospective reviews, and case series were identified and evaluated. Data from these sources were included in this review. DATA SYNTHESIS: CONCLUSIONS: Further comparative trials are needed to more clearly define the role of echinocandins, either as monotherapy or in combination for difficult-to-treat infections, in the pediatric population.
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Authors | Heather L VandenBussche, Dean A Van Loo |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 44
Issue 1
Pg. 166-77
(Jan 2010)
ISSN: 1542-6270 [Electronic] United States |
PMID | 20009006
(Publication Type: Journal Article, Review)
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Chemical References |
- Antifungal Agents
- Echinocandins
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Topics |
- Antifungal Agents
(chemistry, pharmacology)
- Child
- Echinocandins
(chemistry, pharmacology)
- Humans
- Mycoses
(drug therapy)
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