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Isotonic high-sodium oral rehydration solution for increasing sodium absorption in patients with short-bowel syndrome.

Abstract
We compared the effect of a standard oral rehydration solution and a high-sodium polymeric-glucose solution on sodium absorption in short-bowel syndrome. Six patients with high jejunostomy were tested in a random order with the standard solution or a solution containing maltodextrins (18 g Glucidex 12/L) enriched with 2.5 g NaCl/L. Solutions were administered via a nasogastric tube at a rate of 2 mL/min. Jejunal effluent was collected during an 8-h period. The net 8-h fluid absorption was not significantly different in the two periods. Glucose absorption was greater than 90% of the administered amount for both solutions. Net sodium absorption was greater for the maltodextrin solution than for the standard solution (56 +/- 12 vs 24 +/- 20 mmol, P less than 0.05). We conclude that replacement of glucose with maltodextrins and addition of sodium in the standard oral rehydration solution results in improved sodium absorption in short-bowel syndrome.
AuthorsL Beaugerie, J Cosnes, F Verwaerde, H Dupas, P Lamy, J P Gendre, Y Le Quintrec
JournalThe American journal of clinical nutrition (Am J Clin Nutr) Vol. 53 Issue 3 Pg. 769-72 (Mar 1991) ISSN: 0002-9165 [Print] United States
PMID2000833 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Isotonic Solutions
  • Polysaccharides
  • Rehydration Solutions
  • maltodextrin
  • Sodium
  • Glucose
Topics
  • Absorption
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fluid Therapy
  • Glucose
  • Humans
  • Isotonic Solutions
  • Jejunostomy (adverse effects)
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Polysaccharides
  • Rehydration Solutions
  • Short Bowel Syndrome (therapy)
  • Sodium (metabolism)

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