Abstract | BACKGROUND: METHODS: RESULTS: Total IgA was decreased in TS/OCD patients (median 115 mg/100 mL) compared with control subjects (141 mg/100 mL; p = .02). Specific IgA against all antigens, except tubulin were also decreased in the patients (MPB 0 vs. 13 [ELISA units [EU]; myelin-associated glycoprotein 29 vs. 44 EU, p = .04; ganglioside GM1 21 vs. 35 EU, p = .01; lysoganglioside 44 vs. 56 EU, p = .03; tubulin 44 vs. 44 EU, p = .8). The levels of total IgA and anti- myelin basic protein (MBP) IgA were significantly lower in the subgroup of pediatric autoimmune neuropsychiatric disorder associated with Streptococcus (PANDAS) cases (n = 10) than in non-PANDAS cases (n = 9; total IgA 98 mg/100 mL vs. 133 mg/mL, p = .03; anti-MBP IgA 1 vs. 6 EU, p = .03) or healthy control subjects (total IgA 141 mg/100 mL, p = .02; anti-MBP IgA 13 EU, p = .005). CONCLUSIONS: At least some TS/OCD patients may suffer IgA dysgammaglobulinemia, possibly rendering the children more prone to URTI.
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Authors | Ivana Kawikova, Bart P X Grady, Zuzana Tobiasova, Yan Zhang, Aristo Vojdani, Liliya Katsovich, Brian J Richmand, Tae Won Park, Alfred L M Bothwell, James F Leckman |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 67
Issue 7
Pg. 679-83
(Apr 01 2010)
ISSN: 1873-2402 [Electronic] United States |
PMID | 20006327
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
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Topics |
- Child
- Dysgammaglobulinemia
(epidemiology, immunology, physiopathology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulin A
(immunology)
- Immunoglobulin G
(immunology)
- Immunoglobulin M
(immunology)
- Male
- Tourette Syndrome
(epidemiology, immunology, physiopathology)
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