[Clinical efficacy of the biospecific hemosorbent "Liposorb"].

Abstract

The aim of the present work was to evaluate clinical efficacy of the biospecific hemosorbent "Liposorb". The main component of "Liposorb" is polyacrylamide gel containing an immobilized affine ligand (antibiotic polymyxin E-colistyne). 40 patients with abdominal sepsis and peritonitis of different genesis underwent a total of 52 seances of vein-venous extracorporeal hemoperfusion of hemosorbent "Liposorb". Endotoxin level (lipopolysaccharide - LPS) was measured by the turbodimetric method. Blood perfusion through a "Liposorb" column at 50-70 ml/min during 90 minutes permitted to reach stabilization of parameters of systemic hemodynamics. All the patients showed positive dynamics of general well-being, blood gas composition, clinical and biochemical blood analyses. The endotoxin (LPS) level of Gramm-negative flora significantly decreased. It is concluded that hemosorbtion using biospecific polymyxin-containing hemosorbent "Liposorb" effectively removes Gramm-negative endotoxin and leads to stabilization of hemodynamic in patients with Gramm-negative abdominal sepsis.

• Authors: D V Vvedenskiĭ, V P Kirkovskiĭ, V N Gapanovich, A V Starostin, D A Makarevich
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 10 Pg. 40-3 ( 2009) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 20000104 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acrylic Resins
• Anti-Bacterial Agents
• Drug Combinations
• Gels
• polyacrylamide gels
• Colistin

Topics

• Acrylic Resins (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Colistin (therapeutic use)
• Drug Combinations
• Endotoxemia (therapy)
• Follow-Up Studies
• Gels
• Gram-Negative Bacterial Infections (therapy)
• Hemoperfusion (methods)
• Humans
• Middle Aged
• Treatment Outcome