Abstract | BACKGROUND: OBJECTIVE: METHODS: A total of 144 male Sprague-Dawley rats were randomly allocated into a sham operation group (n=48), a severe acute pancreatitis group (n=48), and a pyrrolidine dithiocarbamate-treated group (n=48). All the rats were killed at 1, 3, 6, 12, 24, and 48 h after operation. The pancreas histopathologies were observed and serum amylase levels were tested. Meanwhile, the nuclear factor-kappaB activation, tumor necrosis factor-alpha levels and high-mobility group box protein-1 expression levels in pancreatic tissue were studied. RESULTS: CONCLUSIONS:
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Authors | Zhong Wei Zhang, Qi Yu Zhang, Meng Tao Zhou, Na Xin Liu, Tong Ke Chen, Ye Fan Zhu, Liang Wu |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 55
Issue 9
Pg. 2529-36
(Sep 2010)
ISSN: 1573-2568 [Electronic] United States |
PMID | 19997973
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- HMGB1 Protein
- Hbp1 protein, rat
- NF-kappa B
- Pyrrolidines
- Thiocarbamates
- Tumor Necrosis Factor-alpha
- pyrrolidine dithiocarbamic acid
- Amylases
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Topics |
- Acute Disease
- Amylases
(blood)
- Animals
- Antioxidants
(pharmacology)
- Disease Models, Animal
- Down-Regulation
- HMGB1 Protein
(metabolism)
- Male
- NF-kappa B
(metabolism)
- Pancreas
(drug effects, metabolism, pathology)
- Pancreatitis
(drug therapy, metabolism, pathology)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Severity of Illness Index
- Thiocarbamates
(pharmacology)
- Time Factors
- Tumor Necrosis Factor-alpha
(metabolism)
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