HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Candida pyelonephritis complicating traumatic C5 quadriplegia: diagnosis and management.

Abstract
We present the first reported case of Candida pyelonephritis in a spinal cord injured patient. In addition to multiple courses of empiric antibiotics, the neurogenic bladder and alteration in cell-mediated immunity found in spinal cord injured patients may have increased this patient's susceptibility to fungal disease. A 50-year-old patient with C5 motor functional quadriplegia developed Candid albicans pyelonephritis while undergoing rehabilitation. The patient had several surgical procedures and multiple courses of antibiotic therapy during acute hospitalization. He continued to have a hectic fever curve, leukocytosis with increased band forms, lethargy, and progressive uremia during rehabilitation. Successful investigation of the patient's condition included assessment of serologic tests for Candida precipitin antigen; multiple blood and urine cultures; exclusion of other causes of hectic fever; abdominal computerized tomogram, which revealed a left kidney hypodensity with irregular margins; and a retrograde pyelogram, which demonstrated multiple renal pelvic-filling defects. Cystoscopically placed ureteral stents, which relieved the genitourinary obstruction, drained gross pus from which Candida albicans was cultured; the patient was treated with amphotericin B and showed clinical improvement. Pathogenesis, presentation, diagnosis, and treatment of Candida pyelonephritis are reviewed.
AuthorsK J Sandin, J K Light, M Holzman, W H Donovan
JournalArchives of physical medicine and rehabilitation (Arch Phys Med Rehabil) Vol. 72 Issue 3 Pg. 243-6 (Mar 1991) ISSN: 0003-9993 [Print] United States
PMID1998462 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amphotericin B
Topics
  • Algorithms
  • Amphotericin B (therapeutic use)
  • Candidiasis (diagnosis, etiology, therapy)
  • Humans
  • Male
  • Middle Aged
  • Pyelonephritis (diagnosis, etiology, therapy)
  • Quadriplegia (complications)
  • Spinal Cord Injuries (complications)
  • Tomography, X-Ray Computed
  • Urography

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: