[Efficacy and safety of high-dose dexamethasone-based regimens in the newly diagnosed multiple myeloma patients with renal impairment].

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of high-dose dexamethasone-based regiments in newly diagnosed multiple myeloma patients with renal impairment.

METHODS:

The clinical data of 22 patients with newly diagnosed multiple myeloma patients with renal impairment who received high-dose dexamethasone-based regiments from August 2006 to August 2008 in Peking Union Medical College Hospital were retrospectively reviewed.

RESULTS:

After receiving a median 4 cycles of high-dose dexamethasone-based regiments, renal impairment was reversed in 7 patients (31.8%) with a median time to reversal of 31 days. Sixteen patients (72.7%) achieved overall response, including 7 patients (31.8%) had complete remission / near complete remission. The grade 3 or 4 adverse events included neutropenia (13.6%), infections (22.7%), peripheral neuropathy (9.1%), and ileus (4.5%).

CONCLUSION:

The high-dose dexamethasone-based regiments are safe and effective for newly diagnosed multiple myeloma patients with renal impairment.

• Authors: Jian Li, Dao-Bin Zhou, Li Jiao, Ming-Hui Duan, Wei Zhang, Yong-Qiang Zhao, Ti Shen
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 31 Issue 5 Pg. 567-9 (Oct 2009) ISSN: 1000-503X [Print] China
• PMID: 19968072 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dexamethasone

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Dexamethasone (administration & dosage)
• Female
• Humans
• Male
• Middle Aged
• Multiple Myeloma (complications, drug therapy)
• Prognosis
• Renal Insufficiency (complications)
• Retrospective Studies
• Treatment Outcome