Abstract | STUDY OBJECTIVE: To study clinical features of patient presented with severe hydramnios, associated with hydronephrosis, that was antenatally diagnosed and has been successfully treated immediately after birth. At a molecular level, we investigated the gene expression of key steroidogenic enzymes from the maternal ovary. DESIGN: Ultrasound scan, MRI, semi-quantitative RT-PCR SETTING: The patient was admitted to the University Hospital, University of Crete, Medical School, Greece, where all clinical data has been obtained. Gene expression studies took place at Biosciences, Brunel University, UK. RESULTS: CONCLUSION: This clinical case is the only one that we have found in the current literature where congenital imperforate hymen accompanied with hematocolpos is associated with renal obstruction in combination with polyhydramnios and increase in maternal steroidogenic enzymes.
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Authors | Emmanouil Karteris, Helen Foster, Maria Karamouti, Anastasia Goumenou |
Journal | Journal of pediatric and adolescent gynecology
(J Pediatr Adolesc Gynecol)
Vol. 23
Issue 3
Pg. 136-41
(Jun 2010)
ISSN: 1873-4332 [Electronic] United States |
PMID | 19963411
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2010. Published by Elsevier Inc. |
Chemical References |
- Phosphoproteins
- steroidogenic acute regulatory protein
- Steroid Hydroxylases
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Topics |
- Adult
- Female
- Gene Expression Profiling
- Humans
- Hydrocolpos
(enzymology)
- Hydronephrosis
(diagnostic imaging, enzymology)
- Hymen
(abnormalities)
- Infant, Newborn
- Ovarian Cysts
(complications, metabolism)
- Ovary
(enzymology)
- Phosphoproteins
(genetics, metabolism)
- Polyhydramnios
(diagnostic imaging)
- Pregnancy
- Steroid Hydroxylases
(genetics, metabolism)
- Ultrasonography
- Up-Regulation
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