Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver.

Abstract

AIM:

To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model.

METHODS:

Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus).

RESULTS:

There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls.

CONCLUSION:

This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.

• Authors: Takayuki Takeichi, Shinji Uemoto, Sachiko Minamiguchi, Izumi Takeyoshi, Yukihiro Inomata, Koichi Tanaka, Eiji Kobayashi
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 15 Issue 45 Pg. 5712-5 (Dec 07 2009) ISSN: 2219-2840 [Electronic] United States
• PMID: 19960569 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• Phenylpropionates
• ONO-LB 457
• Peroxidase
• Tacrolimus

Topics

• Animals
• Immunosuppressive Agents (pharmacology)
• Liver (drug effects, enzymology, pathology)
• Male
• Peroxidase (metabolism)
• Phenylpropionates (pharmacology)
• Rats
• Rats, Inbred Lew
• Reperfusion Injury (pathology, prevention & control)
• Tacrolimus (pharmacology)