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Bacterial etiologic agents in the pathogenesis of urinary tract infection.

Abstract
Most of the information available concerning virulence factors of uropathogens is based on studies of Escherichia coli, the commonest cause of urinary tract infections. Earlier studies revealed several phenotypic Escherichia coli virulence factors that influenced both the anatomic level and severity of urinary tract infection. Virulence factors included O antigen serotype, presence and quantity of K capsular polysaccharide, adherence to uroepithelial cells, resistance to serum bactericidal activity, hemolysin, and aerobactin production. The introduction of DNA hybridization methodology has provided a valuable tool for reevaluation of the epidemiology of Escherichia coli infection as well as an alternative to the conventional phenotypic approach for studying the genotypic basis for virulence.
AuthorsJ D Sobel
JournalThe Medical clinics of North America (Med Clin North Am) Vol. 75 Issue 2 Pg. 253-73 (Mar 1991) ISSN: 0025-7125 [Print] United States
PMID1996032 (Publication Type: Journal Article, Review)
Chemical References
  • Lipopolysaccharides
Topics
  • Animals
  • Bacteria (pathogenicity)
  • Bacterial Adhesion
  • Bacterial Infections
  • Humans
  • Lipopolysaccharides (physiology)
  • Urinary Tract Infections
  • Virulence

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