[Severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene: report of two cases and literature review].

Abstract

OBJECTIVE:

To improve the understanding of severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene, and to explore the mechanism of pathogenesis and the relationship between the special gene translocation and severe hypercalcemia.

METHODS:

Two patients with severe hypercalcemia complicated in ALL were reported.

RESULTS:

Two patients with E2A-HLF fusion gene, which is generated by t(17;19) (q22, p13) translocation, suffered relapse of leukemia three months after chemotherapy, and developed severe hypercalcemia. After further chemotherapy, the hypercalcemia symptoms were corrected or alleviated.

CONCLUSION:

Severe hypercalcemia is one of rare complications of ALL. In B cell lymphoblastic leukemia with E2A-HLF fusion gene, the fusion gene showed be closely monitored for evaluating the disease situation.

• Authors: Jun Yang, Xuan Zhou, Bin Wang, Chao Gao, Rui-dong Zhang, Bin Li
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 30 Issue 9 Pg. 615-8 (Sep 2009) ISSN: 0253-2727 [Print] China
• PMID: 19954622 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• DNA-Binding Proteins
• E2a-Hlf fusion protein, human
• Oncogene Proteins, Fusion
• Transcription Factors

Topics

• Child
• DNA-Binding Proteins (genetics)
• Female
• Humans
• Hypercalcemia (etiology, genetics)
• Infant
• Male
• Oncogene Proteins, Fusion (genetics)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, genetics)
• Prognosis
• Transcription Factors (genetics)