Abstract | BACKGROUND: METHODS: We performed a meta-analysis of randomized controlled trials identified in PubMed, Cochrane library and Embase that compared the efficacy and safety of ertapenem with piperacillin/tazobactam for the treatment of complicated infections including cIAIs, APIs, cSSSIs. The primary efficacy outcome was clinical treatment success assessed at the test-of-cure visit. The primary safety outcome was drug related clinical and laboratory adverse events occurred during the treatment and the post-treatment period. RESULT: Six RCTs, involving 3161 patients, were included in our meta-analysis. Ertapenem was associated similar clinical treatment success with piperacillin/tazobactam for complicated infections treatment (clinically evaluable population, 1937 patients, odds ratios: 1.15, 95% confidence intervals: 0.89-1.49; modified intention to treat population, 2855 patients, odds ratios: 1.03, 95% confidence intervals: 0.87-1.22). All of secondary efficacy outcomes analysis obtained similar findings with clinical treatment success. No difference was found about the incidence of drug related adverse events between ertapenem and piperacillin/tazobactam groups. CONCLUSION: This meta-analysis provides evidence that ertapenem 1 g once a day can be used as effectively and safely as recommended dose of piperacillin/tazobactam, for the treatment of complicated infections, particularly of mild to moderate severity. It is an appealing option for the treatment of these complicated infections.
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Authors | Mao Mao An, Zui Zou, Hui Shen, Jun Dong Zhang, Meng Li Chen, Ping Liu, Rui Wang, Yuan Ying Jiang |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 9
Pg. 193
(Dec 02 2009)
ISSN: 1471-2334 [Electronic] England |
PMID | 19951447
(Publication Type: Comparative Study, Journal Article, Meta-Analysis)
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Chemical References |
- Anti-Bacterial Agents
- beta-Lactams
- Penicillanic Acid
- Ertapenem
- Tazobactam
- Piperacillin
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Bacterial Infections
(drug therapy)
- Ertapenem
- Humans
- Penicillanic Acid
(analogs & derivatives, therapeutic use)
- Piperacillin
(therapeutic use)
- Randomized Controlled Trials as Topic
- Tazobactam
- Treatment Outcome
- beta-Lactams
(therapeutic use)
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