Abstract | BACKGROUND/AIMS: METHODS: This retrospective study included 68 patients with acute organophosphate poisoning. We investigated patient survival according to initial parameters, including the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum cholinesterase level, and hemoperfusion and evaluated the mortality according to organophosphate types. RESULTS: Thirteen of the 68 patients died. The agents responsible for mortality were different. The APACHE II score was a significant predictor of mortality (odds ratio [OR], 1.194; p<0.01; 95% confidence interval [CI], 1.089 to 1.309) and respiratory failure (OR, 1.273; p<0.01; 95% CI, 1.122 to 1.444). The mortality was 0% for dichlorvos, malathion, chlorpyrifos and profenofos. However, other organophosphates showed different mortality (16.7% for O-ethyl-O-4-nitrophenyl phenylphosphonothioate, 25% for phenthoate, 37.5% for phosphamidon, 50% for methidathion). The usefulness of hemoperfusion appears to be limited. CONCLUSIONS:
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Authors | Eun-Jung Kang, Su-Jin Seok, Kwon-Hyun Lee, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong |
Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 24
Issue 4
Pg. 362-7
(Dec 2009)
ISSN: 1226-3303 [Print] Korea (South) |
PMID | 19949736
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- APACHE
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cholinesterases
(blood)
- Female
- Humans
- Male
- Middle Aged
- Organophosphate Poisoning
- Poisoning
(mortality)
- Prognosis
- Retrospective Studies
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