Abstract | IMPORTANCE OF THE FIELD:
Tumor targeting with peptides is based on the discovery that receptors for many regulatory peptides are overexpressed in tumor cells, compared with their expression in normal tissues. Consequently, these peptides and their analogues can be used as carriers/targeting moieties for the preparation of diagnostic and therapeutic agents that have increased selectivity and decreased peripheral toxicity. AREAS COVERED IN THIS REVIEW: Here an overview is given of the most relevant gonadotropin-releasing hormone ( GnRH) and somatostatin derivatives, as well as of their applications in cancer diagnosis and therapy. For this purpose, recently published data in these areas (mostly articles published from 2000 to 2009) were reviewed. WHAT THE READER WILL GAIN: TAKE HOME MESSAGE:
Tumor targeting with hormone peptides provides a basis for the development of new diagnostic and therapeutic approaches for cancer.
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Authors | Gábor Mezo, Marilena Manea |
Journal | Expert opinion on drug delivery
(Expert Opin Drug Deliv)
Vol. 7
Issue 1
Pg. 79-96
(Jan 2010)
ISSN: 1744-7593 [Electronic] England |
PMID | 19947889
(Publication Type: Journal Article, Review)
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Chemical References |
- Hormones
- Peptides
- Receptors, LHRH
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Topics |
- Cell Line, Tumor
- Hormones
(therapeutic use)
- Humans
- Neoplasms
(diagnosis, drug therapy, metabolism)
- Peptides
(therapeutic use)
- Receptors, LHRH
(metabolism)
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