Abstract | BACKGROUND: We report the first case of atovaquone/proguanil treatment failure in severe Plasmodium falciparum malaria acquired by a non-immune traveller to the Indian subcontinent. Recrudescent infection was complicated by neurological involvement 14 days after directly observed therapy with atovaquone/proguanil. Sequence analysis of the plasmodial cytochrome b gene confirmed a contribution of atovaquone resistance to treatment failure. The recrudescent isolate had a single mutation at position 268 (Tyr268Cys). Video recordings illustrate dramatic but ephemeral manifestations of malaria with neurological involvement.
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Authors | Thomas L Perry, Prativa Pandey, Jennifer M Grant, Kevin C Kain |
Journal | Open medicine : a peer-reviewed, independent, open-access journal
(Open Med)
Vol. 3
Issue 1
Pg. e10-6
(Jan 20 2009)
ISSN: 1911-2092 [Electronic] Canada |
PMID | 19946387
(Publication Type: Journal Article)
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