Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease.

Abstract

BACKGROUND:

The aim of this work was to compare the prevalence of the metabolic syndrome (MS) and its components between a group of autosomal-dominant polycystic kidney disease (ADPKD) patients with normal kidney function and no prior diagnosis of diabetes and healthy controls.

METHODS:

Forty-nine patients with ADPKD (age 35.9 +/- 11.1 years) with serum creatinine <1.35 mg/dl and 50 healthy controls (36.7 +/- 9.2 years) were enrolled for the study. Physical examination, basic laboratory measurements and oral glucose tolerance test were performed in all subjects.

RESULTS:

In the group of ADPKD patients, when compared to controls, the following values were significantly higher: waist-to-hip ratio (0.84 +/- 0.09 vs. 0.81 +/- 0.10, p = 0.046), systolic blood pressure (133.9 +/- 19.8 vs. 122.2 +/- 14.9 mm Hg, p = 0.0023), diastolic blood pressure (92.9 +/- 12.4 vs. 82.9 +/- 9.3 mm Hg, p < 0.0001), fasting glycemia (91.6 +/- 10.5 vs. 84.5 +/- 9.2 mg/dl, p = 0.04), and HbA(1C) (5.41 +/- 0.35 vs. 5.28 +/- 0.33%, p = 0.06, borderline significance). Adult Treatment Panel III criteria of MS were fulfilled by 14% of patients and 14% of controls, while International Diabetes Federation criteria were fulfilled by 22% of patients and 20% of controls, without any significant difference between the groups.

CONCLUSION:

The presence of ADPKD with normal kidney function is associated with components of MS such as hypertension, abdominal obesity and higher fasting glycemia.

• Authors: Maria Pietrzak-Nowacka, Krzysztof Safranow, Elzbieta Byra, Agnieszka Bińczak-Kuleta, Andrzej Ciechanowicz, Kazimierz Ciechanowski
• Journal: Kidney & blood pressure research (Kidney Blood Press Res) Vol. 32 Issue 6 Pg. 405-10 ( 2009) ISSN: 1423-0143 [Electronic] Switzerland
• PMID: 19940512 (Publication Type: Journal Article)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A

Topics

• Adult
• Anthropometry
• Blood Glucose (physiology)
• Blood Pressure (physiology)
• Body Composition (physiology)
• Diabetes Complications (epidemiology, metabolism)
• Female
• Glucose Tolerance Test
• Glycated Hemoglobin (metabolism)
• Humans
• Kidney (physiopathology)
• Kidney Function Tests
• Male
• Metabolic Syndrome (epidemiology, metabolism)
• Polycystic Kidney, Autosomal Dominant (epidemiology, metabolism)
• Renal Insufficiency (epidemiology, metabolism)
• Waist-Hip Ratio