A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery.

Abstract

OBJECTIVE:

To evaluate the effect of adding dexmedetomidine to a balanced anesthetic technique on postoperative nausea and vomiting after laparoscopic gynecological surgeries.

METHODS:

A prospective double-blind randomized study was designed at Jordan University Hospital, Amman, Jordan between December 2008 and February 2009. Eighty-one female patients in their child-bearing age (17-48 years); American Society of Anesthesiologists (ASA) clinical status I, who were scheduled for elective diagnostic laparoscopic surgeries under general anesthesia were divided into 2 groups. Group D (n=42) received dexmedetomidine infusion, while group P (n=39) received 0.9% sodium chloride infusion along with the balanced anesthesia. The incidence of early (up to 24 hours) postoperative nausea, vomiting, nausea and vomiting, and the need for postoperative rescue anti-emetic medications were recorded.

RESULTS:

The total incidence of postoperative nausea and vomiting decreased significantly in group D; 13 out of 42 patients (31%), compared to group P; 23 out of 39 patients (59%), vomiting alone did not significantly change, the incidence of postoperative nausea, and the use of rescue anti-emetic medications were significantly different. A significant drop in overall consumption of fentanyl and sevoflurane was also noted in group D.

CONCLUSION:

Combining dexmedetomidine to other anesthetic agents, results in more balanced anesthesia and a significant drop in the incidence of postoperative nausea and vomiting after laparoscopic gynecological surgeries.

• Authors: Islam M Massad, Wafa A Mohsen, Asma S Basha, Khaled R Al-Zaben, Mahmoud M Al-Mustafa, Subhi M Alghanem
• Journal: Saudi medical journal (Saudi Med J) Vol. 30 Issue 12 Pg. 1537-41 (Dec 2009) ISSN: 0379-5284 [Print] Saudi Arabia
• PMID: 19936416 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Dexmedetomidine

Topics

• Adolescent
• Adult
• Dexmedetomidine (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Laparoscopy (adverse effects)
• Middle Aged
• Postoperative Nausea and Vomiting (prevention & control)
• Prospective Studies