Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde.

Abstract

BACKGROUND:

Excess mortality from lymphohematopoietic malignancies, in particular myeloid leukemia, and brain cancer has been found in surveys of anatomists, pathologists, and funeral industry workers, all of whom may have worked with formaldehyde. We investigated the relation of mortality to work practices and formaldehyde exposure levels among these professionals to address cancer risk in the funeral industry.

METHODS:

Professionals employed in the funeral industry who died between January 1, 1960, and January 1, 1986, from lymphohematopoietic malignancies (n = 168) or brain tumors (n = 48) (ie, case subjects) were compared with deceased matched control subjects (n = 265) with regard to lifetime work practices and exposures in the funeral industry, which were obtained by interviews with next of kin and coworkers, and to estimated levels of formaldehyde exposure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by use of logistic regression. All statistical tests were two-sided.

RESULTS:

Mortality from myeloid leukemia increased statistically significantly with increasing number of years of embalming (P for trend = .020) and with increasing peak formaldehyde exposure (P for trend = .036). Compared with subjects who performed fewer than 500 lifetime embalmings, mortality from myeloid leukemia was elevated among those who performed embalmings for more than 34 years (OR = 3.9, 95% CI = 1.2 to 12.5, P = .024), who performed more than 3068 embalmings (OR = 3.0, 95% CI = 1.0 to 9.2, P = .057), and those whose estimated cumulative formaldehyde exposure exceeded 9253 parts per million-hours (OR = 3.1; 95% CI = 1.0 to 9.6, P = .047). These exposures were not related to other lymphohematopoietic malignancies or to brain cancer.

CONCLUSION:

Duration of embalming practice and related formaldehyde exposures in the funeral industry were associated with statistically significantly increased risk for mortality from myeloid leukemia.

• Authors: Michael Hauptmann, Patricia A Stewart, Jay H Lubin, Laura E Beane Freeman, Richard W Hornung, Robert F Herrick, Robert N Hoover, Joseph F Fraumeni Jr, Aaron Blair, Richard B Hayes
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 101 Issue 24 Pg. 1696-708 (Dec 16 2009) ISSN: 1460-2105 [Electronic] United States
• PMID: 19933446 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Fixatives
• Formaldehyde

Topics

• Aged
• Aged, 80 and over
• Brain Neoplasms (chemically induced, mortality)
• Female
• Fixatives (adverse effects)
• Formaldehyde (adverse effects)
• Funeral Rites
• Hematologic Neoplasms (chemically induced, mortality)
• Humans
• Leukemia, Myeloid (mortality)
• Lymphoma (chemically induced, mortality)
• Male
• Middle Aged
• Nasopharyngeal Neoplasms (mortality)
• Occupational Diseases (chemically induced, mortality)
• Occupational Exposure (adverse effects)