Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Extracts of seven South African medicinal plants used traditionally for the treatment of pain-related ailments were evaluated. AIMS OF THE STUDY: MATERIALS AND METHODS: RESULTS: At the screening assay concentration (0.25 microg/microl), 13 extracts showed good COX-1 inhibitory activity (>50%), while good activity was observed in 15 extracts against COX-2 enzyme. All the extracts of Crinum moorei (bulbs) showed good inhibition against both COX-1 and COX-2 enzymes. Though not significantly different (P=0.05), the highest COX-1 percentage inhibition (100%) was shown by Aloe ferox leaf PE and Colocasia antiquorum tuber DCM extracts, while Colocasia antiquorum tuber PE extract exhibited the highest (92.7%) percentage inhibition against COX-2. Crinum moorei bulb DCM extract showed the lowest EC(50) value (2.9 microg/ml) in the AChE assay. In addition, good to moderate bioactivities were observed in some extracts of Aloe ferox (leaves), Crinum moorei (bulbs) and Pycnostachys reticulata (leaves) in all the assays. The presence and/or amounts of phenolic compounds varied with plant species. CONCLUSION:
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Authors | O A Fawole, S O Amoo, A R Ndhlala, M E Light, J F Finnie, J Van Staden |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 127
Issue 2
Pg. 235-41
(Feb 03 2010)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19932161
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Antioxidants
- Cholinesterase Inhibitors
- Plant Extracts
- Cyclooxygenase 1
- Cyclooxygenase 2
- Acetylcholinesterase
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Topics |
- Acetylcholinesterase
(metabolism)
- Anti-Inflammatory Agents, Non-Steroidal
(isolation & purification, pharmacology, therapeutic use)
- Antioxidants
(isolation & purification, pharmacology, therapeutic use)
- Cholinesterase Inhibitors
(isolation & purification, pharmacology, therapeutic use)
- Cyclooxygenase 1
(metabolism)
- Cyclooxygenase 2
(metabolism)
- Medicine, African Traditional
(methods)
- Pain
(drug therapy, metabolism)
- Phytotherapy
(methods)
- Plant Extracts
(isolation & purification, pharmacology, therapeutic use)
- Plants, Medicinal
- South Africa
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