Abstract |
We investigated the relative impacts of visceral adiposity and insulin resistance on the metabolic risk profile in middle-aged Japanese men. A cross-sectional study was conducted in 636 nondiabetic Japanese men with a mean age of 51.6 years. Visceral adipose tissue (AT) was assessed using computed tomography, and insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). Metabolic risk factors were diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria: (1) hypertriglyceridemia, (2) low high-density lipoprotein cholesterol, (3) hypertension, (4) impaired fasting glucose, and (5) impaired glucose tolerance. Visceral AT and HOMA-IR were significantly and positively correlated with each other (r = 0.41, P < .001). Using the 75th percentile value as a cut point, those with isolated large visceral AT showed significantly greater odds ratios for each of the 5 risk factors measured except impaired fasting glucose, whereas those with isolated high HOMA-IR showed significantly greater odds ratios for each of the 5 risk factors except hypertriglyceridemia and impaired glucose tolerance, compared with the control group. The combined group (increased visceral AT and HOMA-IR) had the highest odds ratios for all studied risk factors. On logistic regression analysis using visceral AT and HOMA-IR as continuous independent variables, they were each independently associated with most of the metabolic risk factors and their clustering. In conclusion, neither visceral AT nor HOMA-IR stands out as the sole driving force of the risk profile; each makes a significant contribution to metabolic abnormalities in Japanese men.
|
Authors | Rie Oka, Junji Kobayashi, Akihiro Inazu, Kunimasa Yagi, Susumu Miyamoto, Masaru Sakurai, Koshi Nakamura, Katsuyuki Miura, Hideaki Nakagawa, Masakazu Yamagishi |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 59
Issue 5
Pg. 748-54
(May 2010)
ISSN: 1532-8600 [Electronic] United States |
PMID | 19926101
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Blood Glucose
- Insulin
- Triglycerides
- Cholesterol
|
Topics |
- Blood Glucose
(metabolism)
- Blood Pressure
(physiology)
- Cholesterol
(blood)
- Cross-Sectional Studies
- Glucose Tolerance Test
- Humans
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Intra-Abdominal Fat
(metabolism)
- Japan
- Logistic Models
- Male
- Middle Aged
- Tomography, X-Ray Computed
- Triglycerides
(blood)
|