Recrudescent Campylobacter jejuni infection in an immunocompetent adult following experimental infection with a well-characterized organism.

Abstract

The recrudescence of infection with Campylobacter jejuni after appropriate antibiotic treatment has not been previously reported in an immunocompetent adult. We present the complete clinical, microbiologic, and immunologic evaluation of a closely monitored healthy male with recrudescent C. jejuni infection occurring in the absence of immunodeficiency following experimental infection with a well-characterized strain. After antibiotic treatment, the initial infection was clinically cleared and microbiologically undetectable. Subsequently, two episodes of recrudescence occurred, with no change in in vitro antibiotic sensitivity being detected. The immune responses of the individual were compared to those of other participants in the experimental infection study: innate immune responses, including fecal cytokines and C-reactive protein, were intact; however, measures of Campylobacter-specific adaptive immune responses were absent, including serum antibodies, antibody-secreting cells, and in vitro gamma interferon responses. No primary or secondary immunodeficiency was identified. Recrudescent Campylobacter infections after treatment may be more common than has previously been appreciated. This work adds to our understanding of the human immune response to natural Campylobacter infection and reiterates the importance of pathogen-specific adaptive immune responses to this globally important pathogen.

• Authors: Shahida Baqar, David R Tribble, Marya Carmolli, Katrin Sadigh, Frederic Poly, Chad Porter, Catherine J Larsson, Kristen K Pierce, Patricia Guerry, Campylobacter Study Team, Michael Darsley, Beth Kirkpatrick
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 17 Issue 1 Pg. 80-6 (Jan 2010) ISSN: 1556-679X [Electronic] United States
• PMID: 19923572 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Antibodies, Bacterial
• Cytokines
• Interferon-gamma

Topics

• Adult
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Antibodies, Bacterial (blood)
• Antigen-Presenting Cells (immunology)
• Campylobacter Infections (drug therapy, microbiology)
• Campylobacter jejuni (drug effects, isolation & purification)
• Cytokines (analysis)
• Feces (chemistry)
• Gastrointestinal Tract (immunology)
• Humans
• Interferon-gamma (metabolism)
• Leukocytes, Mononuclear (immunology)
• Male
• Microbial Sensitivity Tests
• Recurrence
• Young Adult