Prolonged administration enhances the renoprotective effect of pentoxifylline via anti-inflammatory activity in streptozotocin-induced diabetic nephropathy.

Abstract

The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.

• Authors: Kum Hyun Han, Sang Youb Han, Han Seong Kim, Young Sun Kang, Dae Ryong Cha
• Journal: Inflammation (Inflammation) Vol. 33 Issue 3 Pg. 137-43 (Jun 2010) ISSN: 1573-2576 [Electronic] United States
• PMID: 19921414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• CD68 protein, rat
• Ccl2 protein, rat
• Chemokine CCL2
• RNA, Messenger
• Pentoxifylline

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antigens, CD (metabolism)
• Antigens, Differentiation, Myelomonocytic (metabolism)
• Chemokine CCL2 (genetics, urine)
• Diabetes Mellitus, Experimental (complications, immunology)
• Diabetic Nephropathies (drug therapy, immunology, pathology)
• Dose-Response Relationship, Drug
• Kidney (pathology)
• Macrophages (immunology, pathology)
• Male
• Organ Size (drug effects)
• Pentoxifylline (pharmacology)
• Proteinuria (drug therapy, immunology, pathology)
• RNA, Messenger (metabolism)
• Rats
• Rats, Sprague-Dawley